Our Science
The Science Behind Human Biology Intelligence
CellCircuit is built on more than a decade of research across engineered human biology,
biomaterials, tissue engineering, 3D biofabrication, mechanobiology, phenomics, and
translational science.
Our team's scientific work provides the foundation for engineering human-relevant
biological systems, understanding how cellular context shapes function and disease, and
transforming complex biological evidence into therapeutic insight.
Featured Research
Matrix stress relaxation drives glioblastoma cell response
in viscoelastic biomaterials
Engineered Human Biology & Microenvironments
Research examining how engineered biochemical, mechanical, spatial, and structural cues shape cellular phenotype and function.
Viscoelastic N-cadherin-like interactions maintain neural progenitor cell stemness within 3D matrices
Building better habitats: Spatiotemporal signaling cues in 3D biointerfaces for tailored cellular functionality
Protein ligand and nanotopography separately drive the phenotype of mouse embryonic stem cells
Protein ligand nanopattern size selects for cellular adhesion via hemidesmosomes over focal adhesions
3D Biofabrication & Complex Biological Systems
Research advancing spatial control, multicellular organization, perfusable architectures, and fabrication of complex living systems.
A diffusion-based 3D printing strategy to fabricate self-supporting, perfusable networks
One-step bioprinting of endothelialized, self-supporting arterial and venous networks
Diffusion-based 3D bioprinting strategies
Spatially controlled construction of assembloids using bioprinting
3D bioprinting of dynamic hydrogel bioinks enabled by small molecule modulators
Biomaterials & Dynamic Microenvironments
Research into engineered extracellular matrices, dynamic biomaterials, and material properties that regulate cellular behavior.
Reinforcement of fibrillar collagen hydrogels with bioorthogonal covalent crosslinks
Interpenetrating networks of fibrillar and amorphous collagen promote cell spreading and hydrogel stability
Embedded 3D bioprinting of collagen inks into microgel baths to control hydrogel microstructure and cell spreading
Exploring stimuli-responsive natural processes for the fabrication of high-performance materials
Neural Regeneration & Translational Bioengineering
Research translating engineered biomaterials and controlled delivery systems toward neural repair and regenerative applications.
Explore More Research
Our team's broader research spans biomaterials, tissue engineering, stem cell biology, biofabrication, responsive materials, regenerative medicine, and translational bioengineering.